Cisplatin research

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August undefined, 2024

WebCisplatin is a chemotherapeutic drug that has been used in the treatment of various types of human cancers such as ovarian, lung, head and neck, testicular and bladder. Cisplatin has demonstrated efficacy against various types of cancers such as germ cell tumors, sarcomas, carcinomas as well as lymphomas. WebCisplatin is a chemotherapy drug. You might have it as a treatment for a number of different types of cancer. You might have cisplatin on its own or in combination with other cancer …

Cisplatin - LiverTox - NCBI Bookshelf

WebCisplatin - CAS 15663-27-1, is a platinum coordination complex with potent anti-neoplastic activity. Induces apoptosis in cancer cells, possibly via caspase-3 activation. Synonym … WebJul 14, 2014 · The cisplatin stock solution used for culturing CP.5 cells was prepared in PBS. The cisplatin-resistant cells were maintained in the presence of cisplatin, which was removed from growth medium 3 days before all experiments. flowers queenstown nz

Review on Pharmacology of Cisplatin: Clinical Use, Toxicity and ...

WebSep 20, 2024 · The most common adverse reactions in the two trials (≥25% with difference between arms of >5% compared to cisplatin alone) were vomiting, nausea, decreased hemoglobin, hypernatremia, and... WebSep 23, 2016 · The subsequent intracellular signaling pathway analysis indicated that pAkt and p62 expression levels correlated with alterations in the IC50 values for cisplatin in ovarian cancer, providing an... WebCisplatin is a chemotherapy medication used to treat a number of cancers. These include testicular cancer, ovarian cancer, cervical cancer, bladder cancer, head and neck … flower squash blossom

(PDF) The Discovery and Development of Cisplatin

Say No to DMSO: Dimethylsulfoxide Inactivates Cisplatin, …

Web2 days ago · Overactive gene NAE1 lifts the cell division brake. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used … WebMost sources say that cisplatin is soluble in water and saline at around 1 mg/ml - 2.5 mg/ml depending on the source. I saw in the attached article (under liposome preparation method) that they... green bones acne medicationWeb2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative … flowers quispamsis nb

"WebJun 13, 2005 · Cisplatin, cisplatinum or cis-diamminedichloroplatinum (II) (CDDP) is a platinum-based chemotherapy drug used to treat various types of cancers, including sarcomas, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas and germ cell tumors. It was the first member of its class, which now also includes … " - Cisplatin research

Cisplatin research

FDA approves sodium thiosulfate to reduce the risk of ototoxicity ...

WebJan 14, 2024 · Chemotherapy Always Benefits the Cancer Center. Cancer centers significantly mark up chemotherapy drugs, which I cover in the article The Absurd Markup of Over 300% on Average For Chemotherapy Drugs. It is always very profitable for the chemotherapy center when the patient agrees to use Cisplatin. Due to the margins … WebJul 1, 2001 · Knowledge of the mechanism of action of cisplatin has improved our understanding of resistance. Decreased intracellular concentration due to decreased drug uptake, increased reflux or increased inactivation by sulfhydryl molecules such as glutathione can cause resistance to cisplatin. Increased excision of the adducts from …

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WebCisplatin is a chemotherapy drug that contains the metal platinum. It stops or slows growth of cancer cells and other cells that grow rapidly by damaging their DNA. FDA Approved … WebMar 15, 2003 · Abstract. Ovarian cancer is the leading cause of death among women from gynecological malignancies inthe United States. Resistance to the chemotherapeutic agent cisplatin isa major limitation for the successful treatment of ovarian cancer. In an effort to overcome the cisplatin resistance problem in ovarian cancer treatment, we have sought …

WebResearch Day 2024. Serum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen Poynter, Michelle Roesler & Jeannette Sample. Advisor: Jen Poynter. Keywords: Pediatrics, Germ Cell Tumor. WebApr 1, 2016 · Cisplatin is currently one of the most effective chemotherapeutic drugs used for treating ovarian cancer; however, resistance to cisplatin is common. In this study, we explored an experimental strategy for overcoming cisplatin resistance of human ovarian cancer from the new perspective of cancer cell metabolism.

WebCisplatin is also sometimes used to treat head and neck cancer (including cancer of the mouth, lip, cheek, tongue, palate, throat, tonsils, and sinuses), lung cancer, cancer of the … Web2 days ago · One of the main problems in chemotherapy using platinum drugs as anticancer agents is the resistance phenomenon. Synthesizing and evaluating valid alternative compounds is challenging. This review focuses on the last two years of progress in the studies of platinum (II)- and platinum (IV)-based anticancer complexes. In particular, the …

WebApr 13, 2024 · The chances of cure with this type of chemotherapy are exceptionally high for testicular cancer. However, in some patients the tumor develops cisplatin resistance, which is associated with a reduced survival rate. To get to the bottom of the causes of cisplatin resistance in testicular cancer, the Bonn research team used CRISPR gene scissors.

WebResearch Day 2024. Serum platinum levels and cisplatin induced ototoxicity among pediatric germ cell tumor survivors. Lacy Pehlke. MPH, Epidemiology. Co-Authors: Jen … greenbone hosts from fileWebCisplatin Injection is a sterile, multidose vial without preservatives. Store at 15° to 25°C (59° to 77°F). Do not refrigerate. Protect unopened container from light. The cisplatin remaining in... flowers quispamsisWebChemical Name. cis-Diaminodichloroplatinum. Biological Activity. Potent anticancer agent that blocks DNA synthesis. Induces apoptosis via p53-dependent and -independent … flowers quizzesWebOct 11, 2024 · Defining the mechanisms by which cisplatin enters hair cells remains challenging, as cisplatin can enter cultured cells (see Figure 3A) across the cell membrane via passive diffusion ( Hall et al., 2008 ). In zebrafish neuromasts, hair cells with functional TMC1 channels (see Figure 3B) are more susceptible to cisplatin-induced cytotoxicity ... flowers quitman gaWebAlthough cisplatin, cis-diamminedichloroplatinum(II), has been successfully used in the chemotherapy of cancer for more than 25 years, its biochemical mechanism of action is still unclear. The current accepted paradigm about cisplatin mechanism of action is that the drug induces its cytotoxic proper … flower squirrelWeb2 days ago · Cisplatin is used successfully in the chemotherapy of testicular cancer. However, patients who develop resistance to the cytostatic drug urgently need alternative therapy options. Researchers at... flowers quitoWebcisplatin It is a treatment for a number of different types of cancer. How GC works These chemotherapy drugs destroy quickly dividing cells, such as cancer cells. How you have … greenbone scan interrupted at 0