Irf7 mouse
WebInterferon regulatory receptor 7 (IRF7) is a transcription factor involved in the activation of the type I interferon (IFN) response upon pathogenic infection [3-4]. IRF7 has been implicated downstream of several pattern recognition receptors (PRRs), including TLRs, RLRs, and DNA sensors [2]. WebInterferon regulatory factor 7 (IRF7) is the main transcriptional regulator of type I IFN, and it is crucial for the induction of IFNα/β and the type I IFN-dependent immune response. In this study, we focused on the role of IRF7 in the pathogenicity and immunogenicity of RABV using an IRF7 -/- mouse model.
Irf7 mouse
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WebIRF7 Antibody (PA5-20281) in IHC Immunohistochemistry of IRF7 in mouse spleen tissue with IRF7 Polyclonal Antibody (Product # PA5-20281) at 5 µg/mL. Product Details Product Specific Information A suggested positive control is 293 cell lysate. PA5-20281 can be used with blocking peptide PEP-0415. Target Information WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at …
WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 … WebIRF7 play a major role in the innate immune pathway, interacting with the Toll-like receptor (TLR) adaptor proteins MyD88 and Tirp/TRAM and functioning as an intermediate TLR4 and TLR9 signaling. There are at least four differentially spliced isoforms of IRF7, although their function has not been clearly established. For Research Use Only.
WebApr 7, 2005 · Consistently, Irf7-/- mice are more vulnerable than Myd88-/- mice to viral infection, and this correlates with a marked decrease in serum IFN levels, indicating the … WebJan 10, 2024 · IRF7 is the key transcription factor which induces IFNα expression 9, leading to a second wave of type I IFN release. Since IFNα signals via the IFNAR this leads to a positive feedback loop that...
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WebRestoration of IRF7 in tumor cells isolated from metastatic mouse primary mammary tumors restored the ability to secrete IFN and reduced the metastatic burden in a breast cancer tumor mouse model [165]. Decreased IRF7 expression levels were found to correlate with increased metastatic events in human breast cancer, supporting the notion that ... exercise coach bannockburnWebApr 12, 2024 · IRF7 suppresses hematopoietic regeneration under stress via CXCR4. The role of interferon regulatory factor 7 in the pathogenicity and immunogenicity of rabies … exercise coach parker coWebMar 7, 2024 · Here we used MLL-AF9-induced acute myeloid leukemia (AML) mouse models with IRF7 knockout or overexpression and xenograft mouse models to explore the … exercise coach farragut tnWebIRF7 Antibodies Antibodies that detect IRF7 can be used in several scientific applications, including Western Blot, Immunohistochemistry, Flow Cytometry, Immunocytochemistry … exercise coach cherry hillWebImmunohistochemistry (Paraffin) analysis of IRF7 in paraffin-embedded mouse heart tissue. The section was pre-treated using heat mediated antigen retrieval with Tris-EDTA buffer (pH 8.0-8.4) for 20 minutes.The tissues were blocked in 5% BSA for 30 minutes at room temperature, washed with ddH2O and PBS, and then probed with IRF7 Recombinant ... exercise coach metabolic comebackWebJul 14, 2016 · IRF3-5D, an active form of IRF3, and IRF7Δ247–467, a constitutively active form of IRF7 were constructed as previously described using pFLAG-IRF3, and pFLAG-IRF7 plasmids as templates 38,39,40 ... btc 24 horasWebPhospho-IRF-7 (Ser437/438) (D6M2I) Rabbit mAb (Mouse Specific) recognizes endogenous levels of mouse IRF-7 protein when dually phosphorylated at Ser437 and Ser438. This … btc 2a