Klotho function
WebDec 18, 2024 · In the kidney, Klotho, serving as a co-receptor for FGF23 (fibroblast growth factor-23), promotes urinary excretion of phosphorus and maintains phosphate homeostasis. 19, 20 In mice, Klotho deficiency exaggerates isoproterenol-induced pathological cardiac hypertrophy and remodeling, while Klotho overexpression … WebJul 4, 2024 · Klotho is a well-known anti-aging hormone, which serves as a suppressor of aging through a variety of mechanisms. Aging of skeletal muscle is concomitant with a decrease in muscle stem cell function resulting in impaired regeneration. Here we investigate the functional role of the anti-aging hormone Klotho for muscle stem cell …
Klotho function
Did you know?
WebJan 28, 2024 · Membrane-bound Klotho plays an important role in a wide range of physiological and pathophysiological processes [as recently reviewed in ( 3 )]. For … WebApr 1, 2015 · Transmembrane and Soluble α-Klotho Functions A. Inhibition of the insulin/IGF-1 signaling pathway B. Suppression of WNT signaling C. Participation in Ca 2+ …
Klotho is a transmembrane protein that, in addition to other effects, provides some control over the sensitivity of the organism to insulin and appears to be involved in ageing. Its discovery was documented in 1997 by Makoto Kuro-o et al. The name of the gene comes from Klotho or Clotho, one of the Moirai, or Fates, in Greek mythology, who spins the thread of human life. The klotho protein is a novel β-glucuronidase (EC number 3.2.1.31) capable of hydrolyzing steroid β … WebKlotho is a single-pass transmembrane protein that is highly expressed in the kidney, brain, blood, and urine. This protein hormone is associated with a long, healthy life including healthy kidney function (Kuro-o et al., 1997). …
WebJul 12, 2024 · 6 Klotho Functions Independent of FGF23 6.1 Klotho Inhibits TGF-β. A key protective function of Klotho is the prevention of fibrosis (e.g., pulmonary, renal or cardiac fibrosis), which has been attributed in large part to its ability to block TGF-β, although other pathways contribute (Huang Q, et al., 2024; Mencke et al., 2024b WebFeb 6, 2024 · Klotho, in its various forms, can regulate mineral metabolism via FGF23, suppress Wnt signalling, modify TRPV5 mediated calcium signalling, as well as inhibit the activation of the IGF/insulin...
WebJul 23, 2024 · Early Klotho supplementation and cardiac function. Since cardiac dysfunction is a significant cause of mortality in preterm infants with BPD–PH, we evaluated the potential cardioprotective ...
WebApr 15, 2024 · Klotho concentration in the serum decreases with advancing age, and it also inversely varies with renal function parameters such as creatinine and blood urea nitrogen … mass hospital association official siteWebJun 11, 2024 · Klotho is a natural protein enzyme that exists within the body and brain. This protein is created by the KL gene and is produced in the kidneys. It appears to have a large … mass hortWebNov 17, 2024 · Klotho may be a tumor suppressor in a wide range of malignancies that include breast cancer, cervical cancer, pancreatic cancer, melanoma, gastric cancer, … hydrophobins とはWebFeb 20, 2024 · The Structure and Function of Klotho. Klotho is a protein encoded by the klotho gene (Figure 1). The klotho protein can exist in either a membrane-bound form or a secreted, soluble form. hydrophobingWebDec 24, 2024 · Klotho is a membrane-bound or soluble antiaging protein, whose protective activity is essential for a proper function of many organs. In 1997, an accidental insertion of a transgene led to creation of transgenic mice with several age-related disorders. hydrophobinsWebKlotho is an anti-aging protein with pleiotropic actions that exerts organ protection. Several lines of evidence support the notion that Klotho functions as a human aging-suppression molecule. Polymorphisms of … hydrophobic water contact angleWebApr 15, 2024 · Klotho, a protein that exists in two forms, membrane-bound Klotho and soluble Klotho, and acts as co-receptor for fibroblast growth factor 23 (FGF23), has been shown to be involved in... mass hospital association board of trustees