WebOct 27, 2024 · Here we determined the clinical value, biological functions, and potential mechanisms of RBM15 in HCC. Expression of RBM15 was identified using tissue … WebApr 13, 2024 · N6-methyladenosine (m6A) is the most abundant modification of eukaryotic mRNA and is involved in almost every stage of RNA metabolism. The m6A modification on RNA has been demonstrated to be a regulator of the occurrence and development of a substantial number of diseases, especially cancers. Increasing evidence has shown that …
Human Disease Blood Atlas - RBM15 - The Human Protein Atlas
WebNov 16, 2008 · The putative oncoprotein RBM15-MKL1 has been hypothesized to be involved in the pathogenesis of AMKL in part through a dominant-negative mechanism that impairs normal RBM15 function; our data imply that such an inhibition of normal RBM15 function would in turn lead to diminished c-MYC activity, thus contributing to the aberrant … WebRBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and Wnt. An increasing body of evidence has suggested that RBM15 may play a key function on the development of various blood diseases, such as acute/chronic myeloid leukemia and … greentop activity centre
Functions of N6-methyladenosine in cancer metabolism: from …
WebRBM15 stability is controlled by PRMT1 via CNOT4 -mediated ubiquitylation (8). To investigate the biolog - ical significance of PRMT1‑mediated methylation of RBM15, the present study analyzed the role of the PRMT1-RBM15 axis in megakaryopoiesis. The present study demonstrated that human umbilical cord blood cluster of differentiation WebRBM15, an RNA-binding protein, plays important roles in the growth and apoptosis of cells, especially blood cells through regulating multiple signal pathways such as Notch and … WebThe mRNA export function of RBM15/B has been recognized early on in virology by showing the importance of these proteins and their SPOC domain in the nuclear export of viral mRNA (Hiriart et al ... fnf bamie